Recombinant Dna-Derived Human Insulin-Like Growth Factor II (hIGF-II) Stimulates Growth in Hypophysectomized Rats

C. J. Shaar Lilly Research Laboratories Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN, 46285

F. C. Tinsley Lilly Research Laboratories Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN, 46285

M. C. Smith Lilly Research Laboratories Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN, 46285

J. A. Clemens Lilly Research Laboratories Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN, 46285

B. L. Neubauer Lilly Research Laboratories Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN, 46285

Abstract

Sustained subcutaneous administration of recombinant DNA-derived insulin-like growth factor II to immature female hypophysectomized rats stimulated significant increases in body weight gain, tibial epiphyseal cartilage width, femur hydroxyproline concentrations and a significant decrease in serum urea nitrogen concentrations. Recombinant DNA-derived human growth hormone (Humatrope), administered in the same manner produced similar biological effects. The data support the contention that hIGF-II has anabolic effects when administered to hypophysectomized rats and may be a locally acting mediator of pituitary hormone actions.

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Recombinant Dna-Derived Human Insulin-Like Growth Factor II (hIGF-II) Stimulates Growth in Hypophysectomized Rats

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Recombinant Dna-Derived Human Insulin-Like Growth Factor II (hIGF-II) Stimulates Growth in Hypophysectomized Rats

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