Anti 70 kDa heat shock protein antibodies in sera of patients affected by autoimmune and non-autoimmune thyroid diseases.

A. Paggi II Internal Medicine, University “La Sapienza”, Rome, Italy

M. A. Di Prima Infectious and Tropical Diseases, University “La Sapienza”, Rome, Italy

B. S. Paparo Infectious and Tropical Diseases, University “La Sapienza”, Rome, Italy

C. Pellegrino II Internal Medicine, University “La Sapienza”, Rome, Italy

A. R. Faralli II Internal Medicine, University “La Sapienza”, Rome, Italy

M. T. Sinopoli Infectious and Tropical Diseases, University “La Sapienza”, Rome, Italy

O. Leri Infectious and Tropical Diseases, University “La Sapienza”, Rome, Italy

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Abstract

Twenty eight patients (25F, 3M) affected by autoimmune and non-autoimmune thyroid diseases were studied. HSP 70 antibodies were present in 21.4% of patients. Five of them were affected by Graves' disease and one by De Quervain's thyroiditis. The HSP 70 antibodies mean values of patients were significantly higher than the normals (p < 0.05). This datum was confirmed by Western blotting. The presence of HSP 70 antibodies in the sera of those patients may support the link between the protein and the thyroid autoimmune processes.

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Anti 70 kDa heat shock protein antibodies in sera of patients affected by autoimmune and non-autoimmune thyroid diseases.

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Anti 70 kDa heat shock protein antibodies in sera of patients affected by autoimmune and non-autoimmune thyroid diseases.

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