What do Stereoisomers of Antidepressant Drugs Indicate About the Topography of the Serotonin Uptake Area?

Abstract

Some antidepressant drugs are stereoisomers that have been tested for their effects on serotonin uptake. A three-dimensional analysis of the molecular structure of such drugs has led to a topographical model for the putative serotonin uptake area. This area may consist of four binding sites located on at least three planes, and containing a channel through which serotonin enters the cell. The model may be tested by determining the effects of the enantiomers of citalopram and fluoxetine on serotonin uptake.

Key Words:

• Antidepressant stereoisomers
• 5-HT uptake