Effekt af ketotifen (en histamin-antagonist) ved tardive dyskinesier hos aber

Abstract

Lublin H, Gerlach J. Effect of ketotifen (a histamine antagonist) in tardive dyskinesia in monkeys.

Ketotifen (a histamine H-1 antagonist) was given to 8 Cebus monkeys, which previously had received haloperidol for 2 years. Five monkeys had mild tardive dyskinesia. In rodents ketotifen has been shown to reduce haloperidol-induced hypersensitivity. In the present study ketotifen (single dose, 0.5-10.0 mg/kg, and multiple dose, 2 mg × 2/kg/day for 14 days) did not influence tardive dyskinesia. The monkeys were sedated, and locomotor activity was reduced. Ketotifen did not change the effects of haloperidol (a dopamine D-2 antagonist) or apomorphine (a mixed dopamine D-1/D-2 agonist). The results suggest that the only behavioral changes induced by ketotifen were sedation and decreased locomotion, caused by sedation.

Key Words:

• Apomorphine
• Haloperidol
• Ketotifen
• Tardive dyskinesia