Serotonin-stimulated inositol lipid metabolism in human platelets: Clinical implications

Abstract

Simonsson P, Ferencz I, Ailing C. Serotonin-stimulated inositol lipid metabolism in human platelets: clinical implications.

Human platelets possess serotonin₂ receptors similar to the serotonin; receptors found in the brain. These receptors are coupled to a second-messenger system that uses inositol phospholipids from the cell membrane as substrate. Activation of serotonin₂ receptors results in a formation of inositol phosphates and phosphatidic acid. By measuring these second messengers after receptor stimulation, it is possible to assess the functional state of this receptor. Results from studies on platelets obtained from alcoholics after a period of abuse and from studies on platelets acutely exposed to ethanol are presented. The validity of the peripheral serotonin₂ receptor as a model of CNS receptors in discussed.

Key Words:

• Alcoholism
• Inositol phosphates
• Platelets
• Serotonin₂ receptor