Abstract
Multiple sclerosis (MS) may sometimes emerge with divergent symptoms suggesting a pure psychiatric disorder. In this case report we describe two adolescent girls who were admitted to a psychiatric hospital due to severe behavioral disturbances and depression. In both cases the magnetic resonance imaging (MRI) shoved numerous foci of central nervous system demyelinization. The symptoms had emerged within 1-year before the index hospitalization, which is in line with the previous suggestions that psychopathology in MS often develops concurrently or following the exacerbation of the neurologic disease.