Effect of Immunization with Common Enterobacterial Antigen on Experimental Salmonella Typhimurium Infection of Mice

E. A. Gorzynski Department of Microbiology, School of Medicine, State University of New York at Buffalo, Buffalo, New York, 14214; Public Health Division, Erie County Laboratory, Buffalo, New York, 14202; the Computer Center, Roswell Park Memorial Institute, Buffalo, New York, 14203

R. L. Priore Department of Microbiology, School of Medicine, State University of New York at Buffalo, Buffalo, New York, 14214; Public Health Division, Erie County Laboratory, Buffalo, New York, 14202; the Computer Center, Roswell Park Memorial Institute, Buffalo, New York, 14203

E. Neter Department of Microbiology, School of Medicine, State University of New York at Buffalo, Buffalo, New York, 14214; Public Health Division, Erie County Laboratory, Buffalo, New York, 14202; the Computer Center, Roswell Park Memorial Institute, Buffalo, New York, 14203

Abstract

Common enterobacterial antigen (CA) extracted from cultures of Escherichia & serogroups 014 and 0111 was administered intraperitoneally to Swiss white albino and C57BL/6Ha mice. Seven days after the last of 3 injections, the mice were challenged intraperitoneally with 100 LD₅₀ Salmonella typhimurium C5S. Numbers of living mice were recorded daily and compared with the numbers of living mice in control groups which had received extracts of Staphylococcus aureus or Pseudomonas aeruginosa, devoid of CA, or buffered saline. Both mouse strains immunized with CA showed transient but statistically significant protection; the Swiss white albino mice were the better protected. Further studies are needed to identify the role of CA in cellular and humoral immunity against salmonelloeis.

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Effect of Immunization with Common Enterobacterial Antigen on Experimental Salmonella Typhimurium Infection of Mice

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Effect of Immunization with Common Enterobacterial Antigen on Experimental Salmonella Typhimurium Infection of Mice

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