Immuno-Electron Microscopic Localization of the Encephalitogenic Basic Protein in Myelin

R. M. Herndon Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, 21205; Department of Medical Microbiology, Stanford University School of Medicine, Stanford, California, 94304; and the Department of Neurology, University of California, San Francisco, California, 94122 and the Department of Physiology-Anatomy, University of California, Berkeley, California, 94708

H. C. Rauch Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, 21205; Department of Medical Microbiology, Stanford University School of Medicine, Stanford, California, 94304; and the Department of Neurology, University of California, San Francisco, California, 94122 and the Department of Physiology-Anatomy, University of California, Berkeley, California, 94708

E. R. Einstein Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, 21205; Department of Medical Microbiology, Stanford University School of Medicine, Stanford, California, 94304; and the Department of Neurology, University of California, San Francisco, California, 94122 and the Department of Physiology-Anatomy, University of California, Berkeley, California, 94708

Abstract

Immuno-electron microscopic studies of the localization of encephalitogenic basic protein demonstrate its presence in the major dense line of the myelin sheath. Staining could only be achieved where the myelin was partially disrupted due to a failure of the labelled antibody to penetrate the intact myelin sheath. This finding supports the view that the antigenic determinants of the basic protein are occluded in vivo.

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Immuno-Electron Microscopic Localization of the Encephalitogenic Basic Protein in Myelin

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Immuno-Electron Microscopic Localization of the Encephalitogenic Basic Protein in Myelin

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