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Abstract
An in vitro immune response to lipopolysaccharide was obtained using heat-killed Escherichia coli cells as antigen. Spleen cell cultures from phenotypically normal mice responded to sheep erythrocytes and to lipopolysaccharide. Spleen cell cultures from congenitally athymic (nude) mice failed to respond to sheep erythrocytes but did respond to lipopolysaccharide. These results suggest that the in vitro immune response to lipopolysaccharide does not require the participation of thymus-derived cells.