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Original Article

In Vitro Immune Response to Lipopolysaccharide: Thymus-Derived Cells not Required

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Pages 335-340 | Published online: 07 Jul 2009
 

Abstract

An in vitro immune response to lipopolysaccharide was obtained using heat-killed Escherichia coli cells as antigen. Spleen cell cultures from phenotypically normal mice responded to sheep erythrocytes and to lipopolysaccharide. Spleen cell cultures from congenitally athymic (nude) mice failed to respond to sheep erythrocytes but did respond to lipopolysaccharide. These results suggest that the in vitro immune response to lipopolysaccharide does not require the participation of thymus-derived cells.

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