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Abstract
A simple assay has been devised for the measurement of the activity of the activators of prekallikrein. This method measures the arginine esterase activity of kallikrein, after release by the action of an activator on prekallikrein. Activator samples are incubated with the substrate (normal plasma) for exactly 60 seconds at 25°C and esterase activity of the kallikrein formed is determined by its ability to hydrolyze L-tosyl arginine methyl ester.
The results obtained by this assay closely correlate with the determination of activator activity by the release of bradykinin as determined by radioimmunoassay.