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Abstract
The leucocyte migration test (LMT) has been studied in 20 recipients of renal allografts. Splenic and lymph node cells extracts prepared by homo-genation were used as antigens in the incubation medium. Inhibition of LMT was observed in 4 out of 5 patients with chronic rejection, 2 out of 13 patients in good clinical condition receiving kidney transplant, I in acute rejection and 1 with a non-functioning kidney. In some patients inhibition was already present several days before overt clinical rejection. In patients with good renal function and stable clinical conditions the majority of the tests were negative but 6 out of 11 sera from patients in good condition inhibited the migration of normal leucocytes. We were unable to find a patient with both positive LMT and serum inhibition test (SIT).