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Immunological Communications Volume 3, 1974 - Issue 3
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Original Article

The Encephautogenic Dose Response in Guinea Pigs of the Tryptophan Region of Myelin Basic Protein

Janis Dillaha Young Space Sciences Laboratory University of California, Richmond, California
,
Dorinne Tsuchiya Space Sciences Laboratory University of California, Richmond, California
,
Michael Geier Space Sciences Laboratory University of California, Richmond, California
,
Steven Geier Space Sciences Laboratory University of California, Richmond, California
,
Fred C. Westall The Salk Institute for Biological Studies, Post Office Box 1809, San Diego, California, 92112
,
Millie Thompson The Salk Institute for Biological Studies, Post Office Box 1809, San Diego, California, 92112
,
Richard Cyr The Salk Institute for Biological Studies, Post Office Box 1809, San Diego, California, 92112
,
Elsie Ward The Salk Institute for Biological Studies, Post Office Box 1809, San Diego, California, 92112
&
Francis Yurochko The Salk Institute for Biological Studies, Post Office Box 1809, San Diego, California, 92112
 show all
Pages 219-226 | Published online: 07 Jul 2009
 
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Abstract

The encephalitogenic dose response for the synthetic tryptophan peptide from the basic protein of myelin is given. The best dose in guinea pigs for disease induction using the peptide is between 1 and 3üg. Using doses higher or lower induces EAE in fewer animals.

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