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Immunological Communications Volume 3, 1974 - Issue 5
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Original Article

Determination of Immune Response to Morphine I: Binding of morphine to Rabbit Serum Proteins

K. M. Weesner Department of Microbiology, George Washington University School of Medicine, 2300 Eye Street, N.W., Washington, DC, 20037
&
L. F. Affronti Department of Microbiology, George Washington University School of Medicine, 2300 Eye Street, N.W., Washington, DC, 20037
Pages 423-426 | Published online: 07 Jul 2009
 
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Abstract

As a result of this study we have concluded that the immune response and the proposed immunological mediation of drug tolerance to morphine is not due to the classical mechanism of drug hypersensitivity with morphine binding to a serum protein and acting as a hapten.

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