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Abstract
Mice spleen lymphocytes which can be stimulated non-specifically by B cell mitogens such as lipopoly-saccharides (LPS) or a Nocardia water soluble mitogen (NWSM) are sensitive to cortisone. Experiments were performed in view of evaluating the influence of hydrocortisone on the lymphocyte-dependent antibody (LDA) cytotoxicity of mice spleen cells. In this study the hormone was either administered to the mice or incubated with the cells. Our data demonstrate that the K cells are cortisone-resistant whereas the B lymphocytes -which can be transformed and polyclonally activated by these mitogens- are sensitive to cortisone. It is suggested that resistance to this hormone could be used as a functional marker in order to differentiate these cellular subpopulations.