Immunosuppressive Activity of Mouse Amniotic Fluid

Abstract

Conventional Swiss mice were treated from birth through young adulthood with intraperitoneal injections of homologous mouse amniotic fluid. A significant suppression of the primary splenic plaque-forming cells (PFC) antibody response to sheep red blood cells was demonstrated in these animals. A pronounced suppressive effect by amniotic fluid was noted on the γA and γG PFC, with variable degrees of immunosuppression observed on the γM response.