Resemblance of Blast Responses of C₃H/HeJ Mouse and Rabbit Spleen Lymphocytes to B-Cell Mitogenic Components of E. COLI Cell Walls

Abstract

Nude mice lymphocytes were stimulated by heat-killed E. Coli bacterial cells as well as by various components of their cell walls such as lipopolysaccharide, peptidoglycan and lipoprotein. Only bacterial cells, peptidoglycan and lipoprotein induce a high stimulation of C₃H/HeJ mouse and rabbit lymphocytes. These data show the resemblance of mutant C₃H/HeJ mice to rabbits with regard to blast response induced by various mitogenic components of E. Coli cell walls.