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Abstract
MOPC 104E is a mouse plasmacytoma which produces an IgM (λ) myeloma protein. This IgM protein has a binding specificity for dextran B-1355s. This report describes a variant of the MOPC 104E tumor which secretes a myeloma protein which does not react with the dextran. The apparent variant of MOPC 104E arose spontaneously during routine passage of the MOPC 104E tumors in Balb/C mice and appears to be stable.