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Original Article

Induction of Hapten-Specific Cell-Mediated Immunity in Rhesus Monkeys Treated with Adsorbent Purified Antilymphocyte Antibody

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Pages 559-566 | Published online: 07 Jul 2009
 

Abstract

Rhesus monkeys were treated with sufficient amounts of rabbit antilymphocyte sera and immunoadsorbent purified antilymphocyte antibody to retain full-thickness skin grafts 23 and 29 days respectively. During this immunosuppressed period hapten-specific cell-mediated immunity was induced in six of seven rhesus monkeys immunized with p-azophenylarsono-N-acetyltyrosine (R-tyr) in complete Freund's adjuvant. These observations suggest that in rhesus monkeys different populations of T cells may be responsible for cutaneous sensitization to antigen and rejection of skin grafts.

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