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Abstract
The effects of Δ9-tetrahydrocannabinol (Δ9-THC) on the immune response of murine cells sensitized in vitro was determined using a plaque-forming cell (PFC) assay. Splenic lymphocytes from mice injected with Δ9-THC showed a depressed immunologic response when compared with cells from control animals which were identically semitized in vitro with sheep erythrocytes (SRBC). The direct addition of Δ9-THC to the culture media altered the im-munological response as demonstrated by a reduction in the number of PFC.
