Correlation of Tartrazine Hypersensitivity with Specific Serum IgD Levels

Norman Weliky Department, of Pediatrics, Harbor General Hospital University, Los Angeles, California, 90509

Douglas C. Heiner Department, of Pediatrics, Harbor General Hospital University, Los Angeles, California, 90509

Hiroshi Tamura Department, of Pediatrics, Harbor General Hospital University, Los Angeles, California, 90509; Gunma University Medical School, Maebashi, Japan

Scott Anderson Department, of Pediatrics, Harbor General Hospital University, Los Angeles, California, 90509; Duke University Medical Center, Box 2706, Durham, North Carolina, 27710

Brita Stenius-aarniala University Central Hospital, Helsinki, 29, Finland

Donald F. German The Permanente Medical Group, San Francisco, California, 94100

Clyde D. Hawley The Permanente Medical Group, Livermore, California, 94550

Stephen D. Lockey The Permanente Medical Group, Lancaster, Pennsylvania, 17603

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Abstract

The clinical diagnosis of hypersensitivity to the food dye tartrazine in 16 subjects correlated with levels of tartrazine-specific IgD antibodies determined by a solid phase radioimmunoassay inhibition test. This is the first study associating hypersensitivity to a low molecular weight chemical with an antibody response of the IgD class. There was little or no correlation between clinical sensitivity and IgE antibodies.

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Correlation of Tartrazine Hypersensitivity with Specific Serum IgD Levels

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Correlation of Tartrazine Hypersensitivity with Specific Serum IgD Levels

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