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Abstract
The activation level of thioglycolate (TG)-elicited peritoneal macrophages (Mø) from normal and fibrosarcoma-bearing BALB/c mice was investigated. Lipopolysaccharide was used to distinguish in vitro levels of Mø activation. The results of cytotoxicity assays, which measured nonspecific killing of P815 tumor cells by activated Mø, indicated that tumor-bearing host Mø were primed in situ while normal host Mø remained in a resting state. This level of Mø induction may contribute to the resulting tumor-bearing host T cell immune hyporesponsiveness.