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Abstract
Rabbits immunized with purified Sm and RNP small nuclear ribonucleo-proteins (snRNPs) produced precipitating and hemagglutinating antibodies against these antigens. These antibodies had immunological specificity identical to the naturally occurring SLE anti-Sm/RNP antibodies as demonstrated by immunoprecipitation results and studies involving the characterization of immunoaffinity purified antigens isolated from the rabbit immune and SLE anti-Sm/RNP IgG affinity columns.