De Novo Formation of Immune Complexes in Toman Kidney Allografts

Wei Kuang Wu Department of Microbiology, School of Medicine State University of New York at Buffalo, Buffalo, New York, 14214

Bernice K. Noble Department of Microbiology, School of Medicine State University of New York at Buffalo, Buffalo, New York, 14214

S. Michael Mauer Department of Microbiology, School of Medicine State University of New York at Buffalo, Buffalo, New York, 14214; Department of Pediatrics, School of Medicine University of Minnesota, Minneapolis, Minnesota, 55455

Felix Milgrom Department of Microbiology, School of Medicine State University of New York at Buffalo, Buffalo, New York, 14214

Abstract

Cryostat sections of 11 rejected human renal grafts were selected for positive results in immunofluorescence tests. Immune complexes were detected in glomerular basement membrane (9 cases), tubular basement membrane (3 cases), and vessels (5 cases). Preincubation of the sections with FII of pooled human serum, but not of rabbit serum, prevented the staining of immune complexes for human IgG. These findings were interpreted by the assumption that most complexes under study were produced by reaction of the patient's altered IgG with the rheumatoid-like factor of IgG variety.

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De Novo Formation of Immune Complexes in Toman Kidney Allografts

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De Novo Formation of Immune Complexes in Toman Kidney Allografts

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