Stimulation of Clones Specific for dsDNA or Idiotypes of Anti-dsDNA as a Consequence of BK Virus Inoculation

O. P. Rekvig Department of Immunology, Institute of Medical Biology, University of Tromsø School of Medicine, 9001, Tromsø, Norway

T. Flægstad Department of Immunology Virology, Institute of Medical Biology, University of Tromsø School of Medicine, 9001, Tromsø, Norway

K. Fredriksen Department of Immunology Virology, Institute of Medical Biology, University of Tromsø School of Medicine, 9001, Tromsø, Norway

T. Traavik Department of Immunology Virology, Institute of Medical Biology, University of Tromsø School of Medicine, 9001, Tromsø, Norway

Abstract

The human polyoma virus BK (BKV) has a 5 Kbp double-stranded (ds) DNA genome packed with host cell histones into a minichromo-some. Two out of 5 rabbits inoculated with infectious BKV produced detectable anti-dsDNA antibodies. In two additional rabbits antibodies against idiotypes of anti-dsDNA antibodies were elicited. These findings strongly indicate the existence of immunocompetent anti-dsDNA clones which are regulated, at least in part, through a network mechanism by anti-idiotype antibodies.

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Stimulation of Clones Specific for dsDNA or Idiotypes of Anti-dsDNA as a Consequence of BK Virus Inoculation

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Stimulation of Clones Specific for dsDNA or Idiotypes of Anti-dsDNA as a Consequence of BK Virus Inoculation

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