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Immunological Investigations
A Journal of Molecular and Cellular Immunology
Volume 41, 2012 - Issue 6-7
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Research Article

Indoleamine 2,3-Dioxygenase and Dendritic Cell Tolerogenicity

Jamie L HardenThe State University of New York at Buffalo, Buffalo, New YorkCorrespondence[email protected]
&
Nejat K EgilmezThe State University of New York at Buffalo, Buffalo, New York
Pages 738-764 | Published online: 27 Sep 2012
 
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Abstract

This article summarizes the molecular and cellular mechanisms that regulate the activity of indoleamine 2,3-dioxygenase (IDO), a potent immune-suppressive enzyme, in dendritic cells (DCs). Specific attention is given to differential up-regulation of IDO in distinct DC subsets, its function in immune homeostasis/autoimmunity, infection and cancer; and the associated immunological outcomes. The review will conclude with a discussion of the poorly defined mechanisms that mediate the long-term maintenance of IDO-expression in response to inflammatory stimuli and how selective modulation of IDO activity may be used in the treatment of disease.

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