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Immunological Investigations
A Journal of Molecular and Cellular Immunology
Volume 41, 2012 - Issue 6-7
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Research Article

Negative Regulation of Myeloid-derived Suppressor Cells in Cancer

Peng QuNational Cancer Institute, National Institutes of Health, Frederick, Maryland, USA
,
Kimberly C. BoelteNational Cancer Institute, National Institutes of Health, Frederick, Maryland, USA
&
P. Charles LinNational Cancer Institute, National Institutes of Health, Frederick, Maryland, USACorrespondence[email protected]
Pages 562-580 | Published online: 27 Sep 2012
 
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Abstract

Myeloid-derived suppressor cells (MDSC) are a heterogeneous population of immature myeloid cells with suppressive function on immune response. In this review, we discuss recent studies about mechanisms of expansion and suppressive function of MDSCs during inflammation, infection and autoimmune diseases, as well as pro-angiogenic and pro-metastatic functions of these cells in tumor development. Further, we focus on novel studies of MDSCs and therapeutic approaches to eliminate these cells in cancer.

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