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Abstract
Myeloid derived suppressor cells (MDSCs) are a heterogeneous population of cells that inhibit anti-tumor immunity through a variety of mechanisms. Malignant gliomas are heavily infiltrated by myeloid cells, some of which appear to share biological functions of MDSCs. Our data with mouse de novo gliomas indicate critical roles of these cells in glioma development. This review summarizes the current understanding of MDSC biology in gliomas and discusses therapeutic interventions that can safely reverse the suppressive effects of MDSCs. The insight gained from these findings may lead to the development of novel immunotherapeutic strategies for gliomas.
ACKNOWLEDGMENTS
We would like to thank Kayla McKaveney for her review and editing of the manuscript. Grant Support from: the National Institutes of Health [2R01NS055140, 2P01 NS40923, 1P01CA132714, the Cancer Center Support Grant P3CA047904] and Musella Foundation.
Declaration of interest: The author declares no competing financial interests. The author is responsible for the content and the writing of this paper.
