Anti-Inflammatory Effects of Modified Adenoviral Vectors for Gene Therapy: A View through Animal Models Tested

ABSTRACT

The central dogma of gene therapy relies on the application of novel therapeutic genes to treat or prevent diseases. The main types of vectors used for gene transfer are adenovirus, retrovirus, lentivirus, liposome, and adeno-associated virus vectors. Gene therapy has emerged as a promising alternative for the treatment of inflammatory diseases. The main targets are cytokines, co-stimulatory molecules, and different types of cells from hematological and mesenchymal sources. In this review, we focus on molecules with anti-inflammatory effects used for in vivo gene therapy mediated by adenoviral gene transfer in the treatment of immune-mediated inflammatory diseases, with particular emphasis on autoinflammatory and autoimmune diseases.

KEYWORDS:

• Adenoviruses
• cytokine
• gene therapy
• inflammatory disease
• in vivo model

Acknowledgment

The authors thank Dr. Miguel Angel Cid Baez for his contribution to Figure 1 construction.

Declaration of interest

The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.

Funding

This work was funded in part by the following CONACyT grants: -SEP-CB-2009-01-0128567, -SALUD-2010-138721, -SALUD-2012-01-181124, -INFR-2015-01-254106. The manuscript edition costs were covered in part with PROFOCIE support (to CA-UAZ-207).

Additional information

Funding

This work was funded in part by the following CONACyT grants: -SEP-CB-2009-01-0128567, -SALUD-2010-138721, -SALUD-2012-01-181124, -INFR-2015-01-254106. The manuscript edition costs were covered in part with PROFOCIE support (to CA-UAZ-207).