Serum Interleukin 6, C-Reactive Protein and Pancreatic Secretory Trypsin Inhibitor (Psti) as Acute Phase Reactants After Major Thoraco-Abdominal Surgery

A. Murata Second Department of Surgery, Osaka University Medical School, Fukushima-ku, Osaka, 553, Japan

M. Ogawa Second Department of Surgery, Osaka University Medical School, Fukushima-ku, Osaka, 553, Japan

T. Yasuda Second Department of Surgery, Osaka University Medical School, Fukushima-ku, Osaka, 553, Japan

J. Nishijima Second Department of Surgery, Osaka University Medical School, Fukushima-ku, Osaka, 553, Japan

Y. Oka Second Department of Surgery, Osaka University Medical School, Fukushima-ku, Osaka, 553, Japan

Y. Ohmachi Second Department of Surgery, Osaka University Medical School, Fukushima-ku, Osaka, 553, Japan

N. Hiraoka Second Department of Surgery, Osaka University Medical School, Fukushima-ku, Osaka, 553, Japan

T. Niinobu Second Department of Surgery, Osaka University Medical School, Fukushima-ku, Osaka, 553, Japan

K. Uda Second Department of Surgery, Osaka University Medical School, Fukushima-ku, Osaka, 553, Japan

T. Mori Second Department of Surgery, Osaka University Medical School, Fukushima-ku, Osaka, 553, Japan

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Abstract

We measured serum immunoreactive interleukin 6 (IL-6) levels in patients after major thoraco-abdominal surgery and compared them with changes in serum C-reactive protein (CRP) and pancreatic secretory trypsin inhibitor (PSTI) levels. Serum IL-6 levels were elevated earlier than serum CRP or PSTI. There were significant relationships between the peak levels of serum IL-6 and the operation time (p < 0.05) or the volume of blood loss during surgery (p < 0.05), showing that serum IL-6 can be a useful laboratory test for the evaluation of tissue injuries due to surgical intervention. Though there was a significant relationship between the peak levels of IL-6 and CRP (p < 0.01), there was no relationship between the peak levels of IL-6 and PSTI.

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Serum Interleukin 6, C-Reactive Protein and Pancreatic Secretory Trypsin Inhibitor (Psti) as Acute Phase Reactants After Major Thoraco-Abdominal Surgery

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Serum Interleukin 6, C-Reactive Protein and Pancreatic Secretory Trypsin Inhibitor (Psti) as Acute Phase Reactants After Major Thoraco-Abdominal Surgery

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