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Immunological Investigations
A Journal of Molecular and Cellular Immunology
Volume 20, 1991 - Issue 7
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Original Article

Effect of Thymic Extract on Allogeneic MLR and Mitogen-Induced Responses in Patients with Chronic Active Hepatitis B

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Pages 545-555 | Published online: 07 Jul 2009
 

Abstract

Cell-mediated immune reactions are involved in the development of chronic active hepatitis (CAH-B). The present studies confirm that lymphocyte from patients with CAH-B have a decreased aliogeneic mixed lymphocyte reaction (allo-MLR) and mitogen-induced responses. These abnormalities probably play a role in the immunological dysfunctions underlying chronic liver diseases. Twenty one patients with biopsy-proven CAH-B and a significantly lowered CD4:CD8 cell number ratio were treated with thymic extract (Thymomodulin-TFX) for 6 months. The results of immunological, serological and biochemical findings indicate that this preparation has an immunoregulatory action and produces beneficial clinical effect in patients with CAH-B.

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