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Immunological Investigations
A Journal of Molecular and Cellular Immunology
Volume 22, 1993 - Issue 3
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Original Article

IA Macrophages and Cytokine Networks Contribute to Tumor-Induced Suppression of CD4+ Autoreactive T Cells

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Pages 169-187 | Published online: 07 Jul 2009
 

Abstract

Tumor growth changes the functions and phenotypes of macrophages (Mϕ) and T cells. Suppression of CD4+ T cell autoresponses during tumor growth was contributed primarily by Mϕ. Tumor-induced alterations in the abilities of these cells to mediate autorecognition were assessed through syngeneic mixed lymphocyte reaction (SMLR) assays. Tumor-bearing host (TBH) Mϕ were significantly more suppressive (60–90%) than normal host (NH) Mϕ, and this suppression was caused partly by reduced la expression. TBH la Mϕ were significantly more suppressive (50–80%) than their NH counterparts. The suppression mechanism was controlled partly by prostaglandin E2 (PGE2), because treating cultures with indomethacin and titrated NH and TBH la Mϕ led to increased T-cell responsiveness, although responsiveness never reached levels of assays containing unseparated Mϕ. Blocking studies using anti-interferon-gamma (anti-IFN-γ) monoclonal antibodies (mAb), anti-interleukin 4 (anti-IL-4) mAb, and indomethacin suggested that IFN-γ, IL-4, and PGE2 contributed to tumor-induced Mϕ-mediated suppression. Our results suggested that a quantitative shift in Mϕ phenotype and a qualitative shift in Mϕ function in addition to differences in cytokine-directed accessory activities are partly responsible for tumor-induced suppression CD4+ T cell autoresponses.

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