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Immunological Investigations
A Journal of Molecular and Cellular Immunology
Volume 22, 1993 - Issue 3
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Original Article

Clinical Relevance of Antibodies to Ro/SS-A and La/SS-B in Subacute Cutaneous Lupus Erythematosus and Related Conditions

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Pages 189-203 | Published online: 07 Jul 2009
 

Abstract

Ro/SS-A autoantibodies are frequently associated with subacute cutaneous lupus erythematosus, neonatal lupus erythematosus and Sjögren's syndrome. The Ro/SS-A autoantigen is a ribonucleoprotein complex consisting of at least four protein components and four small cytoplasmic RNA components designated hY RNA 1, 3, 4 and 5. Three of the Ro/SS-A peptides have been isolated and cloned. The function of this ribonucleoprotein complex is as yet unknown.

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