Publication Cover
Immunological Investigations
A Journal of Molecular and Cellular Immunology
Volume 24, 1995 - Issue 6
1
Views
2
CrossRef citations to date
0
Altmetric
Original Article

Altered in vitro Handling of Mycobacterium Avium Complex by Monocytes and Serum from HIV(+) Patients

, , &
Pages 987-998 | Published online: 07 Jul 2009
 

Abstract

In patients with acquired immunodeficiency syndrome (AIDS), mycobacterial diseases are leading opportunistic infections. The reasons for the peculiar propensity for disseminated infection with Mycobacterium avium complex (MAC) remain unclear. We have previously examined, in detail, the ability of monocytes from healthy donors to take up and kill MAC under both nonopsonic and opsonic conditions. We have now evaluated the in vitro ability of peripheral blood monocytes from HIV(+) patients to take up and kill MAC organisms, and have discovered a reduced ability under both nonopsonic and opsonic conditions. This reduction is due to: 1) apparent defect (s) in the phagocytes themselves, and 2) substance (s) in the HIV(+) serum which actively suppresses phagocyte activity.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.