Interferon β Modulates Experimental Autoimmune Encephalomyelitis by Altering the Pattern of Cytokine Secretion

C. L. Yasuda Neuroimmunology Unit, Department of Microbiology and Immunology, University of Campinas—UNICAMP, SP, Brazil

A. Al-sabbagh BioGen Inc., Cambridge, MA, USA

E. C. Oliveira Neuroimmunology Unit, Department of Microbiology and Immunology, University of Campinas—UNICAMP, SP, Brazil

B. M. Diaz-Bardales Neuroimmunology Unit, Department of Microbiology and Immunology, University of Campinas—UNICAMP, SP, Brazil

C. A. A. Garcia Neuroimmunology Unit, Department of Microbiology and Immunology, University of Campinas—UNICAMP, SP, Brazil

L. M-B Santos Neuroimmunology Unit, Department of Microbiology and Immunology, University of Campinas—UNICAMP, SP, BrazilCorrespondence[email protected]

Abstract

The mechanism of action underlying the beneficial effect of IFNβ in Multiple Sclerosis is poorly understood. Experimental Autoimmune Encephalomyelitis (EAE) is the experimental model for Multiple Sclerosis; therefore, we investigated the effects of recombinant mouse IFNβ on the severity of EAE induced in SJL mice and on cytokine production by Th1 and Th2 lymphocytes. The results indicated that rmIFN β reduced the disease activity with an I.P. dosage of 10,000 U/day every other day, and successfully treated EAE mice revealed reduced amounts of IFN γ; no changes in the levels of IL4 were observed, although thera was a significant increase in IL10 and TGFβ production. Beneficial effects on EAE are associated with inhibition of inflammatory cytokines and stimulation of anti-inflammatory cytokines.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Interferon β Modulates Experimental Autoimmune Encephalomyelitis by Altering the Pattern of Cytokine Secretion

Information for

Open access

Opportunities

Help and information

Interferon β Modulates Experimental Autoimmune Encephalomyelitis by Altering the Pattern of Cytokine Secretion

Abstract

Reprints and Corporate Permissions

Academic Permissions

Related research

To cite this article:

Download citation

Information for

Open access

Opportunities

Help and information

Keep up to date

Your download is now in progress and you may close this window

Login or register to access this feature