Leber’s Hereditary Optic Neuropathy Precipitated by Tadalafil Use for Erectile Dysfunction

Abstract

Leber’s hereditary optic neuropathy (LHON) is an inherited condition leading to bilateral centrocaecal scotoma. Phosphodiesterase type-5 (PDE5) inhibitors such as tadalafil are widely used for male erectile dysfunction. We present a case of a middle-aged male whose LHON presented acutely following tadalafil use. It is postulated that this is due to alteration in the optic nerve head perfusion.

KEYWORDS::

• Tadalafil
• Leber’s Hereditary Optic Neuropathy
• LHON
• erectile dysfunction
• optic neuropathy

ACKNOWLEDGMENT

Declaration of interest: The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.