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ABSTRACT
Though the corneoscleral limbus has been studied for more than 150 years, our ability to successfully treat those with limbal stem cell deficiency (LSCD) is still a work in progress. Today, the only definitive cure for LSCD is stem cell transplantation. This review briefly discusses the evolution of our understanding of limbal stem cell function, provides an outline of the history of autologous limbal stem cell (LSC) transplantation, and discusses current techniques and future strategies for LSCD treatment.
ACKNOWLEDGMENTS
The authors acknowledge Lesley Addison, Sunali Goyal, Marie-Claude Robert, Duna Raoof, Silvia Odorcic, Hajirah Saeed, and Delmar Caldwell.
FUNDING
This work was supported in part by an unrestricted grant to the Department of Ophthalmology at Harvard Medical School from Research to Prevent Blindness, New York, NY.
DECLARATION OF INTEREST
The authors report no conflicts of interest. The authors alone are responsible for the content and writing of this article.