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International Reviews of Immunology Volume 31, 2012 - Issue 5
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Research Article

Inhibition of Selective Adhesion Molecules in Treatment of Inflammatory Bowel Disease

Nilanjan GhoshDr. B.C. Roy College of Pharmacy and Allied Health Sciences, Durgapur, IndiaCorrespondence[email protected]
, M. Pharm,
Rituparna ChakiDr. B.C. Roy College of Pharmacy and Allied Health Sciences, Durgapur, India
, M. Pharm &
Subhash C. MandalDepartment of Pharmaceutical Technology, Jadavpur University, Kolkata, India
, M. Pharm, PhD
Pages 410-427 | Accepted 30 Apr 2012, Published online: 19 Oct 2012
 
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Abstract

Lymphocyte infiltration into the intestinal tract in inflammatory bowel disease (IBD) is mediated by interaction between α4 integrin and its specific ligands. Development of monoclonal antibodies against α4 integrin allowed targeting of lymphocyte trafficking into the intestine as a novel therapeutic intervention. Natalizumab, vedolizumab, alicaforsen AJM300, rhuMAb β7, CCX282-B, and PF-00547,659 are few of monoclonal antibodies that have shown high promise in trials with the potential for more attractive benefit:risk ratio than currently available therapies. In this review, an attempt is made to underline the therapeutic potential and the safety of anti-adhesion molecule treatment in IBD.

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