Advanced search
Publication Cover
International Reviews of Immunology Volume 31, 2012 - Issue 5
Submit an article Journal homepage
409
Views
21
CrossRef citations to date
0
Altmetric
Research Article

Cancer Testis Antigens: A Novel Target in Lung Cancer

Maurizio Chiriva-InternatiCorrespondence[email protected]
,
Apurva PandeyDepartment of Internal Medicine, Division of Hematology & Oncology and Pulmonary and Critical Care Medicine, The Southwest Cancer Treatment and Research Center, Texas Tech University Health Sciences Center, Lubbock, Texas, USA
,
Radhi SabaDepartment of Internal Medicine, Division of Hematology & Oncology and Pulmonary and Critical Care Medicine, The Southwest Cancer Treatment and Research Center, Texas Tech University Health Sciences Center, Lubbock, Texas, USA
,
Minji KimDepartment of Internal Medicine, Division of Hematology & Oncology and Pulmonary and Critical Care Medicine, The Southwest Cancer Treatment and Research Center, Texas Tech University Health Sciences Center, Lubbock, Texas, USA
,
Charles SaadehDepartment of Internal Medicine, Division of Hematology & Oncology and Pulmonary and Critical Care Medicine, The Southwest Cancer Treatment and Research Center, Texas Tech University Health Sciences Center, Lubbock, Texas, USA
,
Tiajani LukmanDepartment of Internal Medicine, Division of Hematology & Oncology and Pulmonary and Critical Care Medicine, The Southwest Cancer Treatment and Research Center, Texas Tech University Health Sciences Center, Lubbock, Texas, USA
,
Raffaella ChiaramonteDepartment of Health Science, Università degli Studi di Milano, Italy
,
Marjorie Jenkins
,
Everardo Cobos
,
Cynthia JumperDepartment of Internal Medicine, Division of Hematology & Oncology and Pulmonary and Critical Care Medicine, The Southwest Cancer Treatment and Research Center, Texas Tech University Health Sciences Center, Lubbock, Texas, USA
&
Read AlalawiDepartment of Internal Medicine, Division of Hematology & Oncology and Pulmonary and Critical Care Medicine, The Southwest Cancer Treatment and Research Center, Texas Tech University Health Sciences Center, Lubbock, Texas, USA
 show all
Pages 321-343 | Published online: 19 Oct 2012
 
Sample our Bioscience journals, sign in here to start your access, Latest two full volumes FREE to you for 14 days

Abstract

Lung cancer is the main cause of cancer mortality worldwide. This is mainly due to the fact that it is diagnosed in advanced stage patients, which are no more surgically curable. Consequently, searching for novel treatments and new modalities for early diagnosis offers great promise to improve the clinical outcome. Recently, a new group of antigens, the cancer testis antigens, have been described as possible early diagnostic tools and therapeutic targets in cancer therapy.This review will report emerging evidences of cancer testis antigens deregulation in lung cancer and explore the state of the art of their currently known role and potential as markers for early diagnosis and disease progression and targets of an immunotherapeutic approach aiming to improve the cure rate of this tumor.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related Research Data

CTdatabase: a knowledge-base of high-throughput and curated data on cancer-testis antigens
Source: Oxford University Press (OUP)
Mammalian protein SCP1 forms synaptonemal complex-like structures in the absence of meiotic chromosomes.
Source: American Society for Cell Biology (ASCB)
New paths in human cancer serology.
Source: Rockefeller University Press
Cancer/testis antigens, gametogenesis and cancer.
Source: Springer Science and Business Media LLC
Effect of active smoking on the human bronchial epithelium transcriptome.
Source: Springer Science and Business Media LLC
Mechanisms of autoimmune disease in the testis and ovary
Source: Oxford University Press (OUP)
A gene encoding an antigen recognized by cytolytic T lymphocytes on a human melanoma
Source: American Association for the Advancement of Science (AAAS)
Humoral immune responses of cancer patients against "Cancer-Testis" antigen NY-ESO-1: correlation with clinical events.
Source: Wiley
Major Histocompatibility Complex Expression on Human, Male Germ Cells: A Review
Source: Wiley
Association of sperm protein 17 with A-kinase anchoring protein 3 in flagella
Source: Springer Science and Business Media LLC
CABYR, a Novel Calcium-Binding Tyrosine Phosphorylation-Regulated Fibrous Sheath Protein Involved in Capacitation
Source: Elsevier Science (USA).
Sp17 gene expression in myeloma cells is regulated by promoter methylation
Source: Springer Science and Business Media LLC
Chromatin remodelling and epigenetic features of germ cells
Source: HAL CCSD
Characterization of two non-testis-specific CABYR variants that bind to GSK3β with a proline-rich extensin-like domain
Source: Elsevier BV
Cancer/testis antigen expression and specific cytotoxic T lymphocyte responses in non small cell lung cancer.
Source: Wiley
Melanoma associated antigen (MAGE)-A3 expression in Stages I and II non-small cell lung cancer: results of a multi-center study.
Source: Oxford University Press (OUP)
TAP (NXF1) Belongs to a Multigene Family of Putative RNA Export Factors with a Conserved Modular Architecture
Source: American Society for Microbiology
Bage - a New Gene Encoding An Antigen Recognized On Human Melanomas By Cytolytic T-lymphocytes
Source: Elsevier BV
TheSSXGene Family
Source: Wiley
Clinical significance of cancer/testis antigens expression in patients with non-small cell lung cancer.
Source: Elsevier BV
Expression of cancer-testis antigens MAGE-A3/6 and NY-ESO-1 in non-small-cell lung carcinomas and their relationship with immune cell infiltration.
Source: Springer Science and Business Media LLC
NY-ESO-1 protein expression in primary breast carcinoma and metastases: correlation with CD8+ T-cell and CD79a+ plasmacytic/B-cell infiltration.
Source: Wiley-Blackwell
Melanoma antigen-11 inhibits the hypoxia-inducible factor prolyl hydroxylase 2 and activates hypoxic response.
Source: American Association for Cancer Research (AACR)
Sp17 Allo-CTL
Source: Wiley
DNA hypermethylation in tumorigenesis: epigenetics joins genetics
Source: Elsevier BV
Multiplatform-based molecular subtypes of non-small-cell lung cancer.
Source: Springer Science and Business Media LLC
FSCB, a novel protein kinase A-phosphorylated calcium-binding protein, is a CABYR-binding partner involved in late steps of fibrous sheath biogenesis.
Source: American Society for Biochemistry & Molecular Biology (ASBMB)
Characterization of sperm protein 17 in human somatic and neoplastic tissue.
Source: Elsevier BV
DNA methylation is the primary silencing mechanism for a set of germ line- and tumor-specific genes with a CpG-rich promoter.
Source: American Society for Microbiology
The biology of cancer testis antigens: Putative function, regulation and therapeutic potential
Source: Wiley
A member of the GAGE family of tumor antigens is an anti-apoptotic gene that confers resistance to Fas/CD95/APO-1, Interferon-gamma, taxol and gamma-irradiation.
Source: Informa UK Limited
Serological immune response to cancer testis antigens in patients with pancreatic cancer.
Source: Wiley
Scanlan et al ·Cancer/testis antigens
Source: Wiley
Sequence and localization of the mouse sperm autoantigenic protein, Sp17.
Source: Oxford University Press (OUP)
A NOD/SCID tumor model for human ovarian cancer that allows tracking of tumor progression through the biomarker Sp17.
Source: Elsevier BV

Linking provided by 

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.