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REVIEWS

Interaction Between Helminths and Toll-Like Receptors: Possibilities and Potentials for Asthma Therapy

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Pages 219-248 | Accepted 04 Sep 2015, Published online: 27 Apr 2016
 

Abstract

Toll-like receptors (TLRs) are essential components of the innate immune system. They play an important role in the pathogenesis of allergic diseases, especially asthma. Since TLRs significantly orchestrate innate and adaptive immune response, their manipulation has widely been considered as a potential approach to control asthma symptoms. It is well established that helminths have immunoregulatory effects on host immune responses, especially innate immunity. They release bioactive molecules such as excretory-secretory (ES) products manipulating TLRs expression and signaling. Thus, given the promising results derived from preclinical studies, harnessing helminth-derived molecules affecting TLRs can be considered as a potential biological therapy for allergic diseases. Prospectively, the data that are available at present suggest that, in the near future, it is possible that helminth antigens will offer new therapeutic strategies and druggable targets for fighting allergic diseases. This review describes the interactions between helminths and TLRs and discusses the potential possibilities for asthma therapy. In this opinion paper, the authors aimed to review the updated literatures on the interplay between helminths, TLRs, and asthma with a view to proposing helminth-based asthma therapy.

Acknowledgements

The authors wish to thank Dr. Cory M. Hogaboam (Cedars Sinai Medical Center, Los Angeles, CA, USA) and Dr. Klaus Erb (Boehringer Ingelheim Pharma GmbH, Biberach a.d. Riss, Germany) for helpful discussions and critical comments on the manuscript. The authors are also thankful to H. Khoravany Fard for helpful editorial comments. The authors apologize to those whom they were unable to reference owing to space limitations.

Declaration of interest

The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the article.

Funding

This work was supported by grant number 27984 from vice chancellor of research, Ferdowsi University of Mashhad, Iran.

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