The Function of the CD4 Coreceptor in the Development of T Cells

Abstract

T cells with helper activity can be found in mice that lack expression of the CD4 glycoprotein. The CD4 promoter is active in these cells; they respond to antigens presented by MHC class II molecules; they do not express CD8 and they do not depend on MHC class I for their development. By such criteria, these CD8 T cells resemble normal CD4⁺ helper T cells. The development of the helper lineage in CD4-null mice can be potentiated by expression of transgenes that encode either wild type CD4, or a deletion mutant of CD4 that lacks the cytoplasmic tail and therefore cannot interact with the tyrosine kinase p56^Ick. These observations suggest that CD4 is not absolutely required for the specification of the helper cell lineage. The role of the CD4 molecule in the development of T cells and possible mechanisms by which it achieves its functions are discussed.

Key Words:

• CD4
• CD8
• T cell development
• lck or p56^Ick
• coreceptor