Investigation of Histopathologic Changes in Pelviureteral Junction Obstruction

Abstract

Objectives. This study aimed to determine histopathologic changes in the pelviureteral junction in children with pelviureteral junction obstruction. Material and methods. Seventeen pelviureteral junction specimens obtained from children were divided into two groups: pelviureteral junction obstruction (n = 7) and control (n = 10). Wall thickness of the pelviureteral junction, tunica muscularis of the pelviureteral junction, uroepithelium thickness of the pelviureteral junction, and collagen thickness of the pelviureteral junction were evaluated in resected pelviureteral junctions in children with pelviureteral junction obstruction. Main findings. The mean wall thickness of the pelviureteral junction, mean tunica muscularis of the pelviureteral junction, and uroepithelium thickness of the pelviureteral junction were not significantly higher than those in the control group. Collagen thickness values in the pelviureteral junction obstruction group were significantly higher than those in the control group. Conclusions. Our data suggest that wall thickness (tunica muscularis and uroepithelium) was not significantly increased, but collagen thickness of the ureter was increased in the pelviureteral junctions of children with pelviureteral junction obstruction.

Keywords:

• pelviureteral junction
• pelviureteral junction obstruction
• tunica muscularis
• uroepithelium
• collagen

ACKNOWLEDGMENTS

We would like to thank Dr. Fatih Kara for his help with the statistical analysis. The authors declare no conflicts of interest.