Ketoconazole Treatment of Fungal Infection in Acute Renal Failure

S. Nakasato Pharmacy and Medical Services Veterans Administration Medical Center 5901 East Seventh Street, Long Beach, California, 90822; Department of Medicine, University of California, Irvine, California, 92664

G. M. Shah Pharmacy and Medical Services Veterans Administration Medical Center 5901 East Seventh Street, Long Beach, California, 90822; Department of Medicine, University of California, Irvine, California, 92664

R. L. Morrissey Pharmacy and Medical Services Veterans Administration Medical Center 5901 East Seventh Street, Long Beach, California, 90822; Department of Medicine, University of California, Irvine, California, 92664

R. L. Winer Pharmacy and Medical Services Veterans Administration Medical Center 5901 East Seventh Street, Long Beach, California, 90822; Department of Medicine, University of California, Irvine, California, 92664

Abstract

A patient with diabetes mellitus and acute renal failure requiring hemodialysis developed Candida sepsis which was effectively treated with the oral antifungal drug, ketoconazole. Plasma drug levels during hemodialysis suggested that ketoconazole was not dialyzed, but that its pharmacokinetics, specifically gastrointestinal absorption, may be altered in renal failure.

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Ketoconazole Treatment of Fungal Infection in Acute Renal Failure

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Ketoconazole Treatment of Fungal Infection in Acute Renal Failure

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