Enzyme Biomarkers of Renal Tubular Injury in Arterial Surgery Patients

Abstract

Objective: The aim of this study was to verify whether preoperative diabetes, hypertension, and renal function had any relationship with postoperative tubule function in patients submitted to anesthesia for arterial surgery. Methods: Prospective observational study. One hundred and forty-four patients submitted to anesthesia for arterial surgery enrolled consecutively and divided into four groups: G1 – diabetes and hypertension; G2 – diabetes; G3 – hypertension; and G4 – without hypertension or diabetes. Urine was obtained for laboratory analysis of urinary creatinine (Ucr), alkaline phosphatase (AP), γ-glutamyltransferase (γGT), and blood for cystatin C and creatinine before the surgery (M1) and 24 h after the surgery (M2). Results: Values of γGT, γGT/Ucr, and AP × γGT/Ucr increased at M2 in G4. Patients without renal function compromise (GFR ≥90 mL/min/1.73 m²) presented increased γGT/Ucr and AP × γGT/Ucr values at M2 and those with slightly compromised renal function (60–89 mL/min/1.73 m²) presented increased γGT values at M2. There was no correlation between deltaCystatin C and deltaAP, deltaγGT, deltaγGT/Ucr, deltaAP/Ucr, and deltaAP × γGT/Ucr. Conclusions: Diabetes, hypertension, and preoperative renal function seem to interfere in tubular enzymuria immediately after surgery in arteriopathic patients. However, when these markers do not increase in postoperative period, renal dysfunction cannot be discarded.

• tubular injury
• arterial surgery
• diabetes
• urine enzymes
• renal function

Acknowledgment

Financial support for the study has been provided by FAPESP N° 59.808-3 – FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO.

Declaration of interest: The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.