Abstract
Data of patients with metastases from Wilms' tumor, either at diagnosis or after first treatment, were collected from 25 European centers. Eligible for survival analysis were 293 patients, 142 from SIOP 1, 46 from SIOP 2 and 105 from SIOP 5. There were 134 boys and 159 girls aged between 2 and 216 months with a median of 54 months. The follow-up time for surviving patients was betweeen 6 months and 142 months with a median of 75 months. At the end of the study, 119 patients are alive disease-free and 174 have died, 19 in complications (2 without tumor); one patient died in acute lymphoblastic leukemia. SIOP 2 patients did significantly worse than those from the SIOP 1 and 5 groups. The following variables were significant for the outcome: (a) site, (b) histology, (c) treatment. A possible reason for the low survival in the SIOP 2 patients is discussed.
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