Prediction of Diabetes in Biobreeding/Aburahi Rats by the Measurement of Soluble L-Selectin

Toru Tanaka First Department of Internal Medicine, Kyoto Prefectural University of Medicine, Kyoto, 602, Japan

Naoto Nakamura First Department of Internal Medicine, Kyoto Prefectural University of Medicine, Kyoto, 602, JapanCorrespondence[email protected]

Yoshihiro Kitagawa First Department of Internal Medicine, Kyoto Prefectural University of Medicine, Kyoto, 602, Japan

Hirofumi Shigeta First Department of Internal Medicine, Kyoto Prefectural University of Medicine, Kyoto, 602, Japan

Goji Hasegawa First Department of Internal Medicine, Kyoto Prefectural University of Medicine, Kyoto, 602, Japan

Hiroshi Obayashi Department of Clinical Research, Kyoto Microbiological Institute, Kyoto, 607, Japan

Masayuki Miyasaka Biomedical Center, Osaka University Medical School, Suita, 565, Japan

Hiroyuki Nakao Shionogi Aburahi Laboratory, Shiga, 520, Japan

Susumu Makino Shionogi Aburahi Laboratory, Shiga, 520, Japan

Motoharu Kondo First Department of Internal Medicine, Kyoto Prefectural University of Medicine, Kyoto, 602, Japan

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Abstract

L-selectin was initially identified as a homing receptor, recently soluble L-selectin has been used as a marker of the inflammation. Therefore, we investigated the relation between the development of diabetes and serum L-selectin levels in the Biobreeding (BB) rats. Serum L-selectin were measured from 30 days old to the onset of diabetes or to 90 days old in Biobreeding (BB) rats and Wistar Furth (WF) rats. Significant elevation of L-selectin was found in diabetes prone (DP) rats from 45 days old to the onset of diabetes or through 90 days old. No elevation was found in other strain of rats. In histological study, all of DP rats had insulitis and no other strain of rats had it. Therefore, we conclude that the measurement of serum L-selectin could be useful tool to predict the onset of diabetes or presence of insulitis in BB rats

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Prediction of Diabetes in Biobreeding/Aburahi Rats by the Measurement of Soluble L-Selectin

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Prediction of Diabetes in Biobreeding/Aburahi Rats by the Measurement of Soluble L-Selectin

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