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Abstract
The aim of this study was to examine the frequency of occurrence of autoantibodies against pi-adrenoceptors in patients with hepatitis virus myocarditis (HVM) and its possible correlation with clinical characteristics. A total of 103 patients with viral myocarditis were divided into a positive group (HVM group, n = 29) and a negative group (Non-HVM group, n = 74) according to the laboratory findings regarding their type of hepatitus virus. The study parameters included UCG, ECG, biochemical findings and screening of autoantibodies against β1-adrenoceptor. It was shown that the positive rate of the hepatitis virus was 28.16% (29/103) in patients with viral myocarditis. The severity of myocardial or liver injuries and the frequency of occurrence of autoantibodies against β1-adrenoceptors in patients with viral myocarditis were more pronounced, before treatment, in the HVM group than in the Non-HVM group. The positive rates of the antibodies against the hepatitis virus and the autoantibodies against β1-adrenoceptors were highly consistent in patients with HVM (p < 0.05). In conclusion, the frequency of occurrence of the autoantibodies against β1-adrenoceptors may be one important marker of HVM and, thus, possibly involved in the pathogenesis of the HVM.