IFIH1 gene polymorphisms in type 1 diabetes: genetic association analysis and genotype-phenotype correlation in Chinese Han population

Abstract

The evaluation of susceptibility loci is an important addition to the current predictive and screening models in type 1 diabetes of Chinese Han population. Therefore, the aim of this study is to provide evidence for the association between type 1 diabetes and two polymorphisms (rs3747517, rs1990760) from interferon induced with helicase C domain 1 (IFIH1). Here, 464 Type 1 diabetespatients and 465 control subjects were genotyped for these 2 polymorphisms. The results indicated that the allelic frequencies of rs3747517 revealed a strong association with type 1 diabetes risk (P < 0.001); yet, no significant association was observed on rs1990760(P = 0.76). Furthermore, IFIH1 rs3747517 polymorphism had no influence on the positive rates of pancreatic auto-antibodies, and both of the polymorphisms had no interaction with HLA class I-linked risk or phenotypes. In conclusion, IFIH1 rs3747517, but not rs1990760 polymorphism, plays an important role in type 1 diabetes risk in Chinese Han population.

Keywords::

• IFIH1
• type 1 diabetes
• autoantibody
• HLA
• phenotype

Acknowledgements

We thank a number of general hospitals (Nanjing General Hospital of Nanjing Military Command, Nanjing Drum Tower Hospital, Nanjing Zhongda Hospital, Nanjing First Hospital, Nanjing Children's Hospital, Nanjing Governmental Hospital, The Second Affiliated Hospital of Nanjing Medical University, Subei People's Hospital of Jiangsu Province, Wuxi People's Hospital, Jiangyin People's Hospital of Jiangsu Province, The First Affiliated Hospital of Soochow University, The Second Affiliated Hospital of Soochow University, The First People's Hospital of Kunshan, Huaian No.1 People's Hospital, Huaian No.2 People's Hospital, Nantong First People's Hospital, Affiliated Hospital of Nantong University, Xuzhou City Centre Hospital, The First People's Hospital of Xuzhou, Zhenjiang First People's Hospital, Changzhou No.2 People's Hospital, The First People's Hospital of Lianyungang City, Yancheng No.1 People's Hospital, Binhai People's Hospital of Yancheng City) for their contribution in sample collection. We are very grateful to all patients and other volunteers who participated in this study.

Declaration of interest: The authors declare that there is no duality of interest associated with this manuscript.