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Short Communication

IL-12 receptor 1β deficiency with features of autoimmunity and photosensitivity

, , , , , & show all
Pages 143-146 | Received 15 Oct 2015, Accepted 16 Dec 2015, Published online: 13 Jan 2016
 

Abstract

Primary immunodeficiences are often accompanied by autoimmune phenomena. IL-12 receptor deficiency is a well characterized primary immunodeficiency that leads to propensity to intracellular infections mainly with mycobacteria and Salmonella. We report on two patients with IL-12 receptor β1 deficiency that presented with autoimmune manifestations and photosensitivity dermatitis and describe possible pathogenetic mechanisms leading to development of clinically significant autoimmune phenomena.

Declaration of interest

The authors declare no conflict of interests.

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