Discordant Interleukin 2 Production in Monozygotic Twins Concordant for Systemic Lupus Erythematosus

Kazuto Sato Division of Clinical Immunology, Institute of Rheumatology, Tokyo Women's Medical College, First Department of Internal Medicine, Tokyo Medical and Dental University, Tokyo, Japan

Nobuyuki Miyasaka Division of Clinical Immunology, Institute of Rheumatology, Tokyo Women's Medical College, First Department of Internal Medicine, Tokyo Medical and Dental University, Tokyo, Japan

Kunio Yamaoka Division of Clinical Immunology, Institute of Rheumatology, Tokyo Women's Medical College, First Department of Internal Medicine, Tokyo Medical and Dental University, Tokyo, Japan

Takashi Yamada Division of Clinical Immunology, Institute of Rheumatology, Tokyo Women's Medical College, First Department of Internal Medicine, Tokyo Medical and Dental University, Tokyo, Japan

Takaaki Nishido Division of Clinical Immunology, Institute of Rheumatology, Tokyo Women's Medical College, First Department of Internal Medicine, Tokyo Medical and Dental University, Tokyo, Japan

Masaharu Okuda Division of Clinical Immunology, Institute of Rheumatology, Tokyo Women's Medical College, First Department of Internal Medicine, Tokyo Medical and Dental University, Tokyo, Japan

Kusuki Nishioka Division of Clinical Immunology, Institute of Rheumatology, Tokyo Women's Medical College, First Department of Internal Medicine, Tokyo Medical and Dental University, Tokyo, Japan

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Abstract

We present data from monozygotic twins concordant for SLE. IL-2 production by peripheral blood mononuclear cells from the patients, when they were discordant for SLE activity, were measured employing cellular mixing experiments. Macrophages from active SLE had a suppressive effect on IL-2 production. Furthermore, SLE T cells appeared to have a defect in IL-2 production irrespective of disease activity. These defects might play an important role in the disordered immunoregulation in SLE.

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Discordant Interleukin 2 Production in Monozygotic Twins Concordant for Systemic Lupus Erythematosus

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Discordant Interleukin 2 Production in Monozygotic Twins Concordant for Systemic Lupus Erythematosus

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