The Immunoglobulin Class, the Subclass and the Ratio of k:λ Light Chain of Autoantibodies to human Insulin in Insulin Autoimmune Syndrome

Abstract

The immunoglobulin class, subclass and the k: λ light chain ratio of insulin autoantibodies were determined in the sera of twenty-four patients with insulin autoimmune syndrome. All sera proved to be of the IgG immunoglobulin class but exhibited various IgG₁:IgG₂:IgG₃:IgG₄ ratios. The ratio of k:λ light chain ranged from 1:0.13 to 1:0.75 with the exceptions of two sera that were characterized as IgG₁(k) and IgG₁,(λ).

Key Words:

• Insulin autoantibody
• insulin autoimmune syndrome
• IgG subclass
• light chain